Which serious adverse effect is associated with atorvastatin?

Which serious adverse effect is associated with atorvastatin?

• A. Rhabdomyolysis with renal failure
• B. Hypoglycemia
• C. Cough and throat irritation
• D. Anemia

Answer: (A)

Atorvastatin can cause muscle-related toxicity, and the most serious of these is rhabdomyolysis, a rapid breakdown of muscle tissue that can release myoglobin into the blood and lead to acute kidney injury. This risk rises with higher doses and when combined with other medications that interact (such as certain antibiotics or fibrates) or with strenuous exercise. Because rhabdomyolysis can be life-threatening, clinicians monitor for symptoms like unexplained muscle pain, weakness, or dark urine and check relevant labs (creatine kinase and kidney function). The other listed effects—hypoglycemia, cough and throat irritation, and anemia—are not typical serious adverse effects of atorvastatin. The key safety takeaway is to watch for new muscle symptoms and seek prompt evaluation to prevent possible kidney injury.

Atorvastatin can cause muscle-related toxicity, and the most serious of these is rhabdomyolysis, a rapid breakdown of muscle tissue that can release myoglobin into the blood and lead to acute kidney injury. This risk rises with higher doses and when combined with other medications that interact (such as certain antibiotics or fibrates) or with strenuous exercise. Because rhabdomyolysis can be life-threatening, clinicians monitor for symptoms like unexplained muscle pain, weakness, or dark urine and check relevant labs (creatine kinase and kidney function). The other listed effects—hypoglycemia, cough and throat irritation, and anemia—are not typical serious adverse effects of atorvastatin. The key safety takeaway is to watch for new muscle symptoms and seek prompt evaluation to prevent possible kidney injury.